Publications
Research articles (Click here for a full list)
Publications (past 10 years)
Sullivan R, Hou J, Yu L, Hicks J, Wilk B, Sykes J, Biernaski H, Butler J, Thiessen J, Dharmakumar R, Prato F, Wisenberg G, Kovacs M, Luyt L, Dhanvantari S. Design, Synthesis and Preclinical Evaluation of a High-Affinity 18F-Labelled Radioligand for Myocardial Growth Hormone Secretagogue Receptor 1A Before and After Myocardial Infarction. Journal of Nuclear Medicine. Accepted
(Front Cover) Liu W, Mousa AA, Hopkin A, Wu YF, Thu K, Campbell M, Lees S, Ramachandran R, Hou J. Lysophosphatidic acid receptor 1 (LPA1) antagonists as potential migrastatics for triple negative breast cancer. 2024 ChemMedChem. e202400013-e202400013
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Aksamit N, Hou J, Li Y, Ombuki-Berman B. Integrating Transformers and Many-Objective Optimization for Cancer Drug Design. BMC Bioinformatics, 2024, 25, 208.
Huang J, Bai L, Shi D, Jiang W, Chen P, Dong Y, Zhang X, Peng J, Hou J, Lu Y, Huang X, Tang G, and Huang S, Synthesis and Evaluation of [18F]AlF-NOTA-c-DVAP: A Novel PET Probe for Imaging GRP78 in Cancer. Molecular Pharmaceutics. 2024, 21, 5, 2425–2434
(Book chapter) Zhao D, Kovacs AH, Hou J. Metastasis Inhibition in Cancer. Handbook of Cancer and Immunology. Springer Nature. 2024, https://doi.org/10.1007/978-3-030-80962-1_375-1
Zhao D, Kovacs A, Campbell M, Floriano W, Hou J. Selective Targeting of Aurora Kinase B over A: Uncovering the Structural Basis for Inhibitor Specificity through Molecular Dynamics Simulations. Journal of Molecular Structure. 2023, 1292, 136178
Liu W, Hopkins AM, Yan P, Du S, Luyt LG, Li Y, Hou J, Can machine learning ‘transform’peptides/peptidomimetics into small molecules? A case study with ghrelin receptor ligands. Molecular Diversity, 2023, 27(5),2239-2255.
Xu Y, Huang Z, Wu G, Jin F, Lin S, Zhang C, Zheng J, Liu W, Hou J, Lu YJ. Bioinformatic assay reveal the potential mechanism of Guizhi-Shaoyao-Zhimu decoction against rheumatoid arthritis and mild-to-moderate COVID-19. Computer Methods and Programs in Biomedicine, 2023 107584.
Kovacs AH, Zhao D, Hou J, Aurora B Inhibitors as Cancer Therapeutics. Molecules. 2023 28 (8), 3385.
Zhang YH, Huang XH, Wong WL, Luo JR, Guo XC, Liu W, Hou J, She MT, Jiang WH, Sun N, Lu YJ. A red fluorescent small-molecule for visualization of higher-order cyclic dimeric guanosine monophosphate (c-di-GMP) structure in live bacterial cells and real-time monitoring of biofilm formation on biotic and abiotic surfaces. Sensors and Actuators B: Chemical. 2023, 376, 132992.
Zheng BX, Long W, She MT, Wang Y, Zhao D, Yu J, Leung ASL, Chan KH, Hou J, Lu YJ, Wong WL. A cytoplasm-specific fluorescent ligand for selective imaging of RNA G-quadruplexes in live cancer cells Chemistry–A European Journal. 2023, e202300705.
Long W, Zheng BX, Li Y, Huang XH, Lin DM, Chen CC, Hou J, Wong WL, Zhang K, Lu YJ. Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer. Nucleic Acid Research. 2022, 50(4) 1829–1848.
Liu WJ, Hopkins AM, Hou J. The development of modulators for lysophosphatidic acid receptors: a comprehensive review. Bioorganic Chemistry. 2021,117,105386
Tang L, Yan HY, Wu WB, Zhang CL, Gao ZX, Hou J, Chen DW, Zhai X, Jiang Y. Synthesis and anti-influenza virus effects of novel substituted polycyclic pyridone derivatives modified from Baloxavir. Journal of Medicinal Chemistry. 2021, 64, 19, 14465–14476.
Zheng BX, She MT, Long W, Xu YY, Zhang YH, Huang XH, Liu WJ, Hou J, Wong WL, and Lu YJ, A small-sized benzothiazole-indolium fluorescent probe: The study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging. Chemical Communications, 2020, 56, 15016.
Jin J, Hou J, Long W, Zhang X, Lu YJ, Li D, Zhang K, Wong WL. Synthesis of fluorescent G-quadruplex DNA binding ligands for the comparison of terminal group effects in molecular interaction: phenol versus methoxybenzene. Bioorganic Chemistry, 2020, 99, 103821.
Zhu Y, Hou J, Huang XH, Zhong DX, Long W, Liu W, Lu YJ, Zhang K, Wong WL, Structural modification of nonspecific thiazole orange for ligand-DNA interaction study: Understanding the ligand recognition selectivity towards G4-DNA over duplex-DNA, Journal of Luminescence, 2020,226, 117488
Lalonde T, Fowkes M, Hou J, Thibeault PE, Milne M, Dhanvantari S, Ramachandran R, Luyt LG. Single Amino Acid Replacement in G-7039 Leads to a 70-fold Increase in Binding toward GHS-R1a. ChemMedChem, 2019, 14, 1762-1766. (Front Cover)
Li D, Long W, Hou J, Qiang D, Guo Q, Wong WL, Lu YJ, Zhang K. A series of modified thiazole orange dye as the highly fluorescent G-quadruplex DNA binders: The study of electronic effects of the substituent on 1-methylquinolinium moiety, Journal of Luminescence, 2019, 205, 367-373.
Sun N, Li D, Hou J, Long W, Guo Q, Lu Y, Zhang K, Yuan W, Wong WL. A propeller-like small molecule as a novel G‐quadruplex DNA binder: The study of fluorescent sensing property and preferential interactions with human Telo21 structure. Chemical biology & drug design, 2019, 93, 979-985.
Hou J, Kovacs MS, Dhanvantari S, Luyt LG. Development of candidates for positron emission tomography (PET) imaging of ghrelin receptor in disease: design, synthesis, and evaluation of fluorine-bearing quinazolinone derivatives. Journal of Medicinal Chemistry, 2018, 61 (3), 1261–127
Long W, Lu YJ, Zhang Z, Huang XH, Hou J, Cai SY, Li Y, Du X, Luyt LG, Wong WL, Chow CF. Boosting the turn-on fluorescent signaling ability of thiazole orange dyes: The effectiveness of structural modification site and its unusual interaction behavior with nucleic acids. Dyes and Pigments, 2018, 159, 449-456.
Ali SN, Dayarathna TK, Ali AN, Osumah T, Ahmed M, Cooper TT, Power NE, Zhang D, Kim D, Kim R, St Amant A, Hou J, Tailly T, Yang J, Luyt L, Spagnuolo PA, Burton JP, Razvi H, Leong HS. Drosophila melanogaster as a function-based high-throughput screening model for anti-nephrolithiasis agents in kidney stone patients, Disease models & mechanisms, 2018, 11, dmm035873.
Li D, Hou J, Long W, Lu YJ, Wong WL, Zhang K. A study on a telo21 G-quadruplex DNA specific binding ligand: enhancing the molecular recognition ability via the amino group interactions, RSC Advances, 2018, 8 (36), 20222-20227.
Charron CL, Hou J, McFarland MS, Dhanvantari S, Kovacs MS, Luyt LG. Structure-activity study of ghrelin(1-8) resulting in high affinity fluorine-bearing ligands for the ghrelin receptor. Journal of Medicinal Chemistry, 2017,60 (17), 7256-7266.
Diab S, Abdelaziz AM, Li P, Teo T, Basnet SKC, Noll B, Rahaman MH, Lu J, Hou J, Yu M, Le BT, Albrecht H, Milne RW, Wang S. Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia, European journal of medicinal chemistry, 2017,139, 762-772.
Sun N, Xu MH, Guo XL, Lu YJ, Hou J, Yang SY, Zhang K, Luyt LG, Wong WL, Chow CF. The interaction of a structural flexible small molecule with nucleic acid structures: Investigation of the origin of fluorescence signal discrimination in sensing and the utilization in live cell imaging. Sensors & Actuators: B. Chemical , 2017, 250, 543-551.
Hou J, Charron CL, Fowkes MM, Luyt LG. Bridging computational modeling with amino acid replacements to investigate GHS-R1a-peptidomimetic recognition. European Journal of Medicinal Chemistry 2016, 123, 822-833.
Lu YJ, Deng Q, Hou J, Hu DP, Wang ZY, Zhang K, Luyt LG, Wong WL, Chow CF. Molecular engineering of thiazole orange dye: change of fluorescent signaling from universal to specific upon binding with nucleic acids in bioassay. ACS Chemical Biology 2016, 11, 1019-1029.
Gavin CT, Ali SN, Tailly T, Olvera-Posada D, Alenezi H, Power NE, Hou J, St Amant AH, Luyt LG, Wood S, Wu C, Razvi H, Leong HS. Novel methods of determining urinary calculi composition: petrographic thin Ssectioning of calculi and nanoscale flow cytometry urinalysis. Scientific Reports 2016, 6, 19328.
Teo T, Yang Y, Yu M, Basnet SK, Gillam T, Hou J, Schmid RM, Kumarasiri M, Diab S, Albrecht H, Sykes MJ, Wang S. An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis. European Journal of Medicinal Chemistry 2015, 103, 539-550.
Shan C, Lin J, Hou J, Liu HY, Chen SB, Chen AC, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule. Nucleic Acids Research 2015, 43, 6677-6691.
Hickey JL, Simpson EJ, Hou J, Luyt LG. An integrated imaging probe design: the synthesis of 99mTc/Re-containing macrocyclic peptide scaffolds. Chemistry – A European Journal 2015, 21, 568-578.
Hou J, Chen SB, Zan LP, Ou TM, Tan JH, Luyt LG, Huang ZS. Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach. Chemical communications 2015, 51, 198-201.
Hou J, Teo T, Sykes MJ, Wang S. Insights from molecular dynamics simulations into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase. ACS Medicinal Chemistry Letters 2013, 4 (8), 736–741.
Lin J, Hou J, Xiang HD, Yan YY, Gu YC, Tan JH, Li D, Gu LQ, Ou TM, Huang ZS. Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation. Biochemical and Biophysical Research Communications 2013, 433(4), 368-373.
Wang X, Zhou CX, Yan JW, Hou J, Chen SB, Ou TM, Gu LQ, Huang ZS, Tan JH. Synthesis and evaluation of quinazolone derivatives as a new class of c-KIT G-quadruplex binding ligands. ACS Medicinal Chemistry Letters 2013, 4(10): 909-914.
Li Z, Wang B, Hou J, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS. 2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modeling. Journal of Enzyme Inhibition and Medicinal Chemistry 2013, 28, 583.
Li YP, Weng X, Ning FX, Ou JB, Hou J, Luo HB, Li D, Huang ZS, Huang SL, Gu LQ. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method. Journal of Molecular Graphics and Modelling. 2013, 41, 61-67.
Lu YJ, Deng Q, Hou J, Hu DP, Wang ZY, Zhang K, Luyt LG, Wong WL, Chow CF. Molecular engineering of thiazole orange dye: change of fluorescent signaling from universal to specific upon binding with nucleic acids in bioassay. ACS Chemical Biology 2016, 11, 1019-1029.
Gavin CT, Ali SN, Tailly T, Olvera-Posada D, Alenezi H, Power NE, Hou J, St Amant AH, Luyt LG, Wood S, Wu C, Razvi H, Leong HS. Novel methods of determining urinary calculi composition: petrographic thin Ssectioning of calculi and nanoscale flow cytometry urinalysis. Scientific Reports 2016, 6, 19328.
Teo T, Yang Y, Yu M, Basnet SK, Gillam T, Hou J, Schmid RM, Kumarasiri M, Diab S, Albrecht H, Sykes MJ, Wang S. An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis. European Journal of Medicinal Chemistry 2015, 103, 539-550.
Shan C, Lin J, Hou J, Liu HY, Chen SB, Chen AC, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule. Nucleic Acids Research 2015, 43, 6677-6691.
Hickey JL, Simpson EJ, Hou J, Luyt LG. An integrated imaging probe design: the synthesis of 99mTc/Re-containing macrocyclic peptide scaffolds. Chemistry – A European Journal 2015, 21, 568-578.
Hou J, Chen SB, Zan LP, Ou TM, Tan JH, Luyt LG, Huang ZS. Identification of a selective G-quadruplex DNA binder using a multistep virtual screening approach. Chemical communications 2015, 51, 198-201.
Hou J, Teo T, Sykes MJ, Wang S. Insights from molecular dynamics simulations into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase. ACS Medicinal Chemistry Letters 2013, 4 (8), 736–741.
Lin J, Hou J, Xiang HD, Yan YY, Gu YC, Tan JH, Li D, Gu LQ, Ou TM, Huang ZS. Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation. Biochemical and Biophysical Research Communications 2013, 433(4), 368-373.
Wang X, Zhou CX, Yan JW, Hou J, Chen SB, Ou TM, Gu LQ, Huang ZS, Tan JH. Synthesis and evaluation of quinazolone derivatives as a new class of c-KIT G-quadruplex binding ligands. ACS Medicinal Chemistry Letters 2013, 4(10): 909-914.
Li Z, Wang B, Hou J, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS. 2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modeling. Journal of Enzyme Inhibition and Medicinal Chemistry 2013, 28, 583.
Li YP, Weng X, Ning FX, Ou JB, Hou J, Luo HB, Li D, Huang ZS, Huang SL, Gu LQ. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method. Journal of Molecular Graphics and Modelling. 2013, 41, 61-67.
Patents
- Quinazolinone derivative useful for imaging. US Patent App. 16/500,867
- The preparation and evaluation of quinnazolidone derivative as anti-cancer drugs. China. CN101857595. 2010-05-21; Patent Status: Completed; Date Issued: 2012-11-21
- The preparation and evaluation of 9-N-substituted berberine derivatives as anti-cancer drugs. China. CN101255158. 2008-03-28; Patent Status: Completed; Date Issued: 2010-06-23
